Targeted Drug-delivery Approaches By Nanoparticulate Carriers In The Therapy Of Inflammatory Diseases

Limitations in therapy induced by adverse effects due to unselective drug availability and therefore the use of potentially too high doses are a common problem. One prominent example for this dilemma are inflammatory diseases.



The therapeutic drawback can be overcome using nanocarrier-based drug targeting strategies which improve the selective delivery of drugs to the site of action, the so called drug targeting.



Specific uptake of nanoparticles by immune related cells in inflamed barriers offers selective drug targeting to the inflamed tissue. Common inflammatory disorders like rheumatoid arthritis, multiple sclerosis, uveitis or inflammatory bowel disease can be efficiently treated using nanocarrier-based drug delivery strategies which avoid common adverse effects.



Source
Journal of the Royal Society Interface